Subacute Transplantation of Native and Genetically Engineered Neural Progenitors Seeded on Microsphere Scaffolds Promote Repair and Functional Recovery After Traumatic Brain Injury
نویسندگان
چکیده
منابع مشابه
Optimizing a multifunctional microsphere scaffold to improve neural precursor cell transplantation for traumatic brain injury repair.
Tissue engineering using stem cells is widely used to repair damaged tissues in diverse biological systems; however, this approach has met with less success in regenerating the central nervous system (CNS). In this study we optimized and characterized the surface chemistry of chitosan-based scaffolds for CNS repair. To maintain radial glial cell (RGC) character of primitive neural precursors, f...
متن کاملPost-traumatic neural depression and neurobehavioral recovery after brain injury.
There are an estimated 2 million traumatic brain injuries (TBIs) each year in the United States, making the yearly incidence eight times greater than that of breast cancer and 34 times greater than HIV/AIDS. Still, it remains a "silent epidemic" because TBI results in persistent neurobehavioral impairment, without necessarily imparting a physical scar. The present review is a comparative analys...
متن کاملThe potential of neural transplantation for brain repair and regeneration following traumatic brain injury.
Traumatic brain injury is a major health problem worldwide. Currently, there is no effective treatment to improve neural structural repair and functional recovery of patients in the clinic. Cell transplantation is a potential strategy to repair and regenerate the injured brain. This review article summarized recent development in cell transplantation studies for post-traumatic brain injury brai...
متن کاملO5: A Self-Assembled Nanopeptide Scaffold Combined with Mesenchymal Stem Cells Improved Functional Recovery after Traumatic Brain Injury in Rats
Traumatic Brain Injury (TBI) is a major cause of death and disability worldwide. TBI can cause cognitive and memory function impairments which Current medical setting is not able to cure. In this study, we hypothesized that mesenchymal stem cells derived from Adipose tissue transplanted with RADA1- GGS IKVAV (GSIKVAV) can rescue cognitive function. An acute model of TBI was ca...
متن کاملTransplantation of Olfactory Mucosa Improve Functional Recovery and Axonal Regeneration Following Sciatic Nerve Repair in Rats
Background: Olfactory ensheathing glia (OEG) has been shown to have a neuroprotective effect after being transplanted in rats with spinal cord injury. This study was conducted to determine the possible beneficial results of olfactory mucosa transplantation (OMT) which is a source of OEG on functional recovery and axonal regeneration after transection of the sciatic nerve. Methods: In this study...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: ASN Neuro
سال: 2019
ISSN: 1759-0914,1759-0914
DOI: 10.1177/1759091419830186